CRMP-2(Phospho Thr514) Polyclonal Antibody

This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance| growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse| and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders| and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

The CRMP-2(Phospho Thr514) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of CRMP-2 protein phosphorylated at threonine 514. This antibody is produced using advanced polyclonal antibody production techniques, ensuring high affinity and specificity towards the target protein.

CRMP-2, also known as collapsin response mediator protein 2, plays a crucial role in neuronal development and axon guidance. Phosphorylation of CRMP-2 at threonine 514 has been implicated in various neurological disorders, including Alzheimer's disease and schizophrenia. Therefore, the ability to accurately measure the phosphorylation status of CRMP-2 is of great importance in understanding the underlying mechanisms of these diseases.

The CRMP-2(Phospho Thr514) Polyclonal Antibody has been extensively validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits excellent sensitivity and specificity, enabling reliable and reproducible results.

This antibody is supplied as a liquid formulation, allowing for easy handling and storage. It is provided in a convenient size, ensuring cost-effectiveness and minimizing waste. Additionally, it is compatible with a wide range of sample types, including cell lysates, tissue extracts, and purified proteins.

In summary, the CRMP-2(Phospho Thr514) Polyclonal Antibody is a valuable tool for researchers and clinicians studying the role of CRMP-2 phosphorylation in neurological disorders. Its high specificity, sensitivity, and versatility make it an essential component of any laboratory investigating the molecular mechanisms underlying these diseases.