Cortactin(Phospho Tyr466) Polyclonal Antibody

This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis| the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.

The Cortactin(Phospho Tyr466) Polyclonal Antibody is a highly specific and sensitive tool for the detection and analysis of Cortactin protein phosphorylated at Tyr466. This antibody has been rigorously validated for its performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence.

Cortactin is a cytoskeletal protein that plays a crucial role in cell migration, adhesion, and invasion. Phosphorylation of Cortactin at Tyr466 has been implicated in the regulation of actin dynamics and cell motility. Therefore, the ability to accurately detect and quantify the phosphorylation status of Cortactin at Tyr466 is of great importance in understanding the underlying mechanisms of cellular processes.

The Cortactin(Phospho Tyr466) Polyclonal Antibody exhibits exceptional specificity and sensitivity, ensuring reliable and reproducible results. It has been extensively characterized using various cell lysates and tissues, demonstrating its ability to specifically recognize the phosphorylated form of Cortactin at Tyr466.

This antibody is supplied as a liquid formulation, allowing for easy and convenient handling. It is provided in a ready-to-use format, eliminating the need for any additional preparation steps. The Cortactin(Phospho Tyr466) Polyclonal Antibody is suitable for use in both research and clinical settings, enabling scientists and clinicians to investigate the role of Cortactin phosphorylation in various biological processes and diseases.

In summary, the Cortactin(Phospho Tyr466) Polyclonal Antibody is a reliable and versatile tool for the detection and analysis of Cortactin protein phosphorylated at Tyr466. Its exceptional specificity, sensitivity, and ease of use make it an invaluable asset for researchers and clinicians alike.