Claudin-3(Phospho Tyr219) Polyclonal Antibody

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets| forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet| with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene| a member of the claudin family| is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin| and shares aa sequence similarity with a putative apoptosis-related protein found in rat.

The Claudin-3(Phospho Tyr219) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Claudin-3 protein phosphorylated at Tyr219. This antibody is produced using advanced techniques and high-quality materials to ensure optimal performance and reliability.

Claudin-3 is a key component of tight junctions, which play a crucial role in maintaining the integrity and barrier function of epithelial and endothelial cell layers. Phosphorylation of Claudin-3 at Tyr219 has been implicated in various cellular processes, including cell adhesion, migration, and signaling.

The Claudin-3(Phospho Tyr219) Polyclonal Antibody exhibits exceptional specificity towards the phosphorylated form of Claudin-3, enabling accurate and precise detection in various experimental settings. It has been extensively validated for use in Western blotting, immunohistochemistry, and immunofluorescence applications.

This antibody is supplied as a liquid formulation, allowing for easy and convenient handling. It is provided in a ready-to-use format, eliminating the need for time-consuming and error-prone reconstitution steps. The antibody is also available in different sizes to accommodate various experimental requirements.

With its superior sensitivity and specificity, the Claudin-3(Phospho Tyr219) Polyclonal Antibody is an indispensable tool for researchers studying tight junctions, epithelial and endothelial cell biology, and related fields. Its reliable performance and consistent results make it an ideal choice for both basic research and clinical applications.