Chk2(Phospho Thr68) Polyclonal Antibody

In response to DNA damage and replication blocks| cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated| the encoded protein is known to inhibit CDC25C phosphatase| preventing entry into mitosis| and has been shown to stabilize the tumor suppressor protein p53| leading to cell cycle arrest in G1. In addition| this protein interacts with and phosphorylates BRCA1| allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome| a highly penetrant familial cancer phenotype usually associated with inherited mutati

The Chk2(Phospho Thr68) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of Chk2 protein phosphorylated at threonine 68. This antibody is produced using advanced techniques and rigorous quality control measures to ensure optimal performance and reliability.

Chk2, also known as checkpoint kinase 2, is a critical regulator of the DNA damage response pathway. Phosphorylation of Chk2 at threonine 68 is a key event in its activation and subsequent signaling cascade. Therefore, the ability to accurately measure the phosphorylation status of Chk2 at this specific site is of utmost importance in understanding its role in cellular processes such as cell cycle control, DNA repair, and apoptosis.

The Chk2(Phospho Thr68) Polyclonal Antibody exhibits exceptional specificity towards the phosphorylated form of Chk2 at threonine 68, with minimal cross-reactivity to non-phosphorylated Chk2 or other related proteins. This high specificity ensures reliable and accurate results, minimizing false positives and false negatives.

Furthermore, this antibody demonstrates excellent sensitivity, allowing for the detection of low levels of phosphorylated Chk2 in various sample types. Its robust performance enables researchers to confidently analyze Chk2 phosphorylation levels in both basic research and clinical applications.

The Chk2(Phospho Thr68) Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is suitable for various experimental techniques, including Western blotting, immunoprecipitation, and immunofluorescence. The antibody is provided in a convenient size and format, ensuring cost-effectiveness and ease of use.

In summary, the Chk2(Phospho Thr68) Polyclonal Antibody is a highly reliable and specific tool for the detection and quantification of Chk2 phosphorylated at threonine 68. Its exceptional sensitivity and robust performance make it an invaluable asset for researchers studying the DNA damage response pathway and its implications in various cellular processes.