ALK(Phospho-Tyr1278/1282/1283) Rabbit Polyclonal Antibody

This gene encodes a receptor tyrosine kinase| which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain| an hydrophobic stretch corresponding to a single pass transmembrane region| and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged| mutated| or amplified in a series of tumours including anaplastic large cell lymphomas| neuroblastoma| and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene| which result in creation of multiple fusion genes in tumourigenesis| including ALK (chromosome 2)/EML4 (chromosome 2)| ALK/RANBP2 (chromosome 2)| ALK/ATIC (chromosome 2)| ALK/TFG (chromosome 3)| ALK/NPM1 (chromosome 5)| ALK/SQSTM1 (chromosome

The ALK(Phospho-Tyr1278/1282/1283) Rabbit Polyclonal Antibody is a highly specific and sensitive tool for the detection and analysis of ALK protein phosphorylation at tyrosine residues 1278, 1282, and 1283. This antibody is produced using high-quality rabbit polyclonal antibodies, ensuring reliable and reproducible results.

The ALK protein, also known as anaplastic lymphoma kinase, is a receptor tyrosine kinase that plays a crucial role in various cellular processes, including cell growth, differentiation, and survival. Dysregulation of ALK signaling has been implicated in the development and progression of several cancers, making it an important target for therapeutic intervention.

This antibody is designed to specifically recognize and bind to the phosphorylated form of ALK at tyrosine residues 1278, 1282, and 1283. It has been extensively validated for its specificity and sensitivity in various experimental settings, including Western blotting, immunoprecipitation, and immunofluorescence.

The ALK(Phospho-Tyr1278/1282/1283) Rabbit Polyclonal Antibody offers several advantages over other commercially available antibodies. Its high specificity ensures minimal cross-reactivity with non-phosphorylated ALK or other proteins, reducing the risk of false-positive results. Additionally, its high sensitivity allows for the detection of low levels of phosphorylated ALK, enabling accurate quantification and analysis.

This antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size and concentration, allowing for easy handling and storage. Each batch of antibody undergoes rigorous quality control testing to ensure consistent performance and reliability.

In summary, the ALK(Phospho-Tyr1278/1282/1283) Rabbit Polyclonal Antibody is a valuable tool for researchers studying ALK signaling and its role in cancer biology. Its high specificity, sensitivity, and reliability make it an ideal choice for a wide range of applications, including protein expression analysis, pathway elucidation, and drug discovery.