ALK(Phospho-Tyr1078) Rabbit Polyclonal Antibody

This gene encodes a receptor tyrosine kinase| which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain| an hydrophobic stretch corresponding to a single pass transmembrane region| and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged| mutated| or amplified in a series of tumours including anaplastic large cell lymphomas| neuroblastoma| and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene| which result in creation of multiple fusion genes in tumourigenesis| including ALK (chromosome 2)/EML4 (chromosome 2)| ALK/RANBP2 (chromosome 2)| ALK/ATIC (chromosome 2)| ALK/TFG (chromosome 3)| ALK/NPM1 (chromosome 5)| ALK/SQSTM1 (chromosome

The ALK(Phospho-Tyr1078) Rabbit Polyclonal Antibody is a highly specific and sensitive tool for the detection and analysis of ALK protein phosphorylated at tyrosine 1078. This antibody has been rigorously validated and exhibits exceptional performance in various applications, including Western blotting, immunoprecipitation, and immunohistochemistry.

The ALK protein, also known as anaplastic lymphoma kinase, plays a crucial role in cell growth, differentiation, and survival. Phosphorylation of tyrosine 1078 is a key event in the activation of ALK signaling pathways, making it an important target for research and therapeutic interventions.

This polyclonal antibody has been developed using state-of-the-art techniques and exhibits high affinity and specificity towards the phosphorylated form of ALK at tyrosine 1078. It has been extensively tested and validated to ensure reliable and reproducible results.

The ALK(Phospho-Tyr1078) Rabbit Polyclonal Antibody offers several advantages over other antibodies in the market. Its high sensitivity allows for the detection of low levels of phosphorylated ALK, enabling researchers to study subtle changes in ALK signaling. Additionally, its broad reactivity across various species and tissue types makes it a versatile tool for a wide range of experimental settings.

This antibody is supplied as a liquid formulation, ensuring ease of use and convenience. It is provided in a ready-to-use format, eliminating the need for time-consuming and error-prone antibody dilutions. The antibody is also available in different sizes to accommodate various experimental needs.

In summary, the ALK(Phospho-Tyr1078) Rabbit Polyclonal Antibody is a reliable and efficient tool for the detection and analysis of phosphorylated ALK at tyrosine 1078. Its high sensitivity, broad reactivity, and convenient formulation make it an ideal choice for researchers studying ALK signaling pathways and its implications in various diseases and therapeutic interventions.