Atm(Phospho Ser1981) Polyclonal Antibody

The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus| it functions as a regulator of a wide variety of downstream proteins| including tumor suppressor proteins p53 and BRCA1| checkpoint kinase CHK2| checkpoint proteins RAD17 and RAD9| and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia| an autosomal recessive disorder.

The Atm (Phospho Ser1981) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of Atm protein phosphorylated at Ser1981. This antibody is produced using advanced techniques and rigorous quality control measures to ensure optimal performance and reliability.

Atm, also known as Ataxia Telangiectasia Mutated, is a crucial protein involved in the cellular response to DNA damage. Phosphorylation of Atm at Ser1981 is a key event in the activation of Atm kinase activity, which plays a vital role in DNA repair, cell cycle checkpoint control, and apoptosis.

The Atm (Phospho Ser1981) Polyclonal Antibody exhibits exceptional specificity towards the phosphorylated form of Atm at Ser1981, enabling accurate and precise detection in various experimental applications, including Western blotting, immunohistochemistry, and immunofluorescence.

This antibody is produced using high-quality immunogens and purified through a multi-step process to ensure minimal cross-reactivity and maximum sensitivity. It has been extensively validated and optimized for use in diverse research areas, including cancer biology, genotoxic stress response, and DNA damage repair mechanisms.

With its superior performance characteristics, the Atm (Phospho Ser1981) Polyclonal Antibody offers researchers a reliable tool to investigate the role of Atm phosphorylation in cellular processes and disease pathogenesis. Its exceptional sensitivity and specificity make it an invaluable asset for both basic research and clinical applications.

Order the Atm (Phospho Ser1981) Polyclonal Antibody today and unlock new insights into the intricate mechanisms governing DNA damage response and repair, ultimately contributing to advancements in the fields of cancer biology, genetic disorders, and therapeutic interventions.