IGF-I Receptor beta(Phospho-Tyr980) Rabbit Polyclonal Antibody

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

The IGF-I Receptor beta(Phospho-Tyr980) Rabbit Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of the phosphorylated form of the IGF-I receptor beta subunit at tyrosine 980 residue. This antibody is produced using high-quality rabbit polyclonal antibodies, ensuring excellent performance and reliability in various applications.

The IGF-I receptor beta plays a crucial role in mediating the biological effects of insulin-like growth factor-I (IGF-I), a key regulator of cell growth, differentiation, and survival. Phosphorylation of the receptor at tyrosine 980 residue is known to be involved in the activation of downstream signaling pathways, leading to cellular responses such as proliferation and survival.

This antibody has been extensively validated for its specificity and sensitivity in various experimental settings, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits minimal cross-reactivity with other related proteins, ensuring accurate and reliable results.

With its high affinity and specificity, the IGF-I Receptor beta(Phospho-Tyr980) Rabbit Polyclonal Antibody is an indispensable tool for researchers studying the IGF-I signaling pathway and its role in various physiological and pathological processes. Its reliable performance and versatility make it suitable for a wide range of applications in both basic research and clinical studies.

Order the IGF-I Receptor beta(Phospho-Tyr980) Rabbit Polyclonal Antibody today and unlock new insights into the intricate mechanisms of IGF-I signaling, advancing your research in the field of cellular biology and beyond.