IGF-I Receptor beta(Phospho-Tyr1316) Rabbit Polyclonal Antibody

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

The IGF-I Receptor beta(Phospho-Tyr1316) Rabbit Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of the phosphorylated form of the IGF-I receptor beta subunit at tyrosine 1316. This antibody is produced using high-quality rabbit polyclonal antibodies, ensuring excellent performance and reproducibility.

The IGF-I receptor plays a crucial role in various cellular processes, including cell growth, differentiation, and survival. Phosphorylation of the receptor at specific tyrosine residues, such as Tyr1316, is known to regulate its activity and downstream signaling pathways. Therefore, the ability to specifically detect and quantify the phosphorylated form of the IGF-I receptor beta subunit is essential for understanding its functional role in cellular processes.

This antibody has been extensively validated for its specificity and sensitivity in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits minimal cross-reactivity with non-phosphorylated forms of the IGF-I receptor beta subunit, ensuring accurate and reliable results.

With its high affinity and specificity, the IGF-I Receptor beta(Phospho-Tyr1316) Rabbit Polyclonal Antibody is an indispensable tool for researchers studying the IGF-I receptor signaling pathway and its involvement in various physiological and pathological conditions. Its reliable performance and reproducibility make it an ideal choice for both basic research and clinical applications.