Phospho-AR (S94) Polyclonal Antibody

The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. AR contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.

Introducing the Phospho-AR (S94) Polyclonal Antibody, a cutting-edge scientific tool meticulously designed to facilitate advanced research in the field of molecular biology. This antibody, derived from a polyclonal source, exhibits exceptional specificity and sensitivity, enabling precise detection and analysis of phosphorylated Androgen Receptor (AR) at serine 94 residue.

Crafted with utmost precision and utilizing state-of-the-art technology, the Phospho-AR (S94) Polyclonal Antibody offers researchers an invaluable resource to unravel the intricate mechanisms underlying AR phosphorylation. Its high affinity for the phosphorylated AR at serine 94 ensures accurate identification and quantification of this critical post-translational modification, thereby shedding light on the functional implications and regulatory pathways associated with AR signaling.

The Phospho-AR (S94) Polyclonal Antibody boasts an exceptional performance profile, exhibiting minimal cross-reactivity with non-phosphorylated AR and other related proteins. This attribute guarantees unparalleled specificity, minimizing the risk of false-positive results and confounding data interpretation. Moreover, its remarkable sensitivity empowers researchers to detect even low levels of phosphorylated AR, facilitating the investigation of subtle changes in AR phosphorylation dynamics under various experimental conditions.

This antibody is meticulously validated through rigorous quality control measures, ensuring consistent and reliable results across diverse experimental setups. Its compatibility with various applications, including Western blotting, immunoprecipitation, and immunofluorescence, further enhances its versatility and utility in a wide range of research endeavors.

The Phospho-AR (S94) Polyclonal Antibody is supplied in a convenient and user-friendly format, enabling seamless integration into existing laboratory protocols. With its exceptional performance, reliability, and ease of use, this antibody represents an indispensable tool for scientists and researchers striving to unravel the intricate complexities of AR phosphorylation and its impact on cellular processes.

Choose the Phospho-AR (S94) Polyclonal Antibody to unlock new frontiers in molecular biology research and gain unprecedented insights into the dynamic world of AR signaling.