Phospho-ATF-2 (S472) Polyclonal Antibody

ATF2 encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The activating transcription factor 2 has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene.

Introducing the Phospho-ATF-2 (S472) Polyclonal Antibody, a cutting-edge scientific tool meticulously designed to facilitate advanced research in the field of molecular biology. This antibody, derived from a polyclonal source, exhibits exceptional specificity and sensitivity, enabling accurate detection and quantification of phosphorylated ATF-2 at serine 472 residue.

Crafted with utmost precision, this antibody showcases unparalleled affinity towards the phosphorylated form of ATF-2, ensuring reliable and reproducible results. Its robust performance is attributed to the rigorous purification process, which guarantees minimal cross-reactivity with non-phosphorylated ATF-2 or other proteins, thereby minimizing false positives and enhancing experimental accuracy.

The Phospho-ATF-2 (S472) Polyclonal Antibody is an indispensable tool for elucidating the intricate signaling pathways involving ATF-2 phosphorylation. Its application extends to a wide range of research areas, including cancer biology, cellular stress response, and gene regulation. By enabling the precise detection and quantification of phosphorylated ATF-2, this antibody empowers researchers to unravel the molecular mechanisms underlying various physiological and pathological processes.

This antibody is supplied in a convenient and user-friendly format, ensuring ease of use and compatibility with diverse experimental techniques, such as Western blotting, immunohistochemistry, and immunofluorescence. Its exceptional performance, coupled with its versatility, renders it an invaluable asset for both basic and translational research endeavors.

In summary, the Phospho-ATF-2 (S472) Polyclonal Antibody represents a pinnacle of scientific innovation, offering researchers an unparalleled tool to explore the intricate world of molecular biology. With its exceptional specificity, sensitivity, and compatibility with various experimental techniques, this antibody is poised to revolutionize the understanding of ATF-2 phosphorylation and its implications in diverse biological processes.