Phospho-Bcl-x (T115) Polyclonal Antibody

The protein encoded by BCL2L1 (BCL2 like 1) belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator.

The Phospho-Bcl-x (T115) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of phosphorylated Bcl-x protein at threonine 115 residue. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the target protein.

Bcl-x is a member of the Bcl-2 family of proteins, which play a crucial role in regulating apoptosis, or programmed cell death. Phosphorylation of Bcl-x at threonine 115 has been implicated in the modulation of its anti-apoptotic activity. Therefore, the Phospho-Bcl-x (T115) Polyclonal Antibody serves as an invaluable tool for researchers studying the intricate mechanisms underlying cell survival and death.

This antibody has been rigorously validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits exceptional sensitivity and specificity, enabling accurate and reliable detection of phosphorylated Bcl-x protein in various biological samples.

The Phospho-Bcl-x (T115) Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming and error-prone antibody preparation. It is compatible with a wide range of experimental conditions and can be used in both routine laboratory settings and high-throughput screening applications.

With its exceptional performance and reliability, the Phospho-Bcl-x (T115) Polyclonal Antibody is an indispensable tool for researchers investigating the intricate signaling pathways involved in cell survival and apoptosis.