Phospho-ACAP1 (S554) Polyclonal Antibody

ACAP1, also designated Centaurin-β 1 (CENTB1 or Cnt-β1), is a member of the ADP ribosylation factor family of ARF6 GTPase-activating proteins (GAP). GAPs are important regulators of Arf function by controlling the return of ARF to its inactive state. ACAP1 is related to AGAP1 and ASAP1, and all three proteins are similarly expressed in fibroblast cells such as NIH/3T3. Internalization and recycling of integrin receptors is important in cell adhesion and migration modulation, and once inside a cell, proteins and membranes are transported to the endosome where they are sorted for recycling or degradation. ACAP1 promotes cargo sorting by associating directly to recycling cargo proteins. Preventing this interaction inhibits protein recycling. ACAP1 binds transferrin receptors, promoting their transport to the plasma membrane from the endosome. Akt induced phosphorylation of ACAP1 at Ser 554 regulates ACAP1 interaction to integrin in endosomes, and downregulation of Akt or ACAP1 may inhibit cell migration on Fibronectin.

Introducing the Phospho-ACAP1 (S554) Polyclonal Antibody, a cutting-edge scientific tool meticulously designed to facilitate advanced research in the field of molecular biology. This antibody, derived from a polyclonal source, has been specifically engineered to target and detect phosphorylated ACAP1 at the serine 554 residue.

With its exceptional specificity and sensitivity, the Phospho-ACAP1 (S554) Polyclonal Antibody offers an unparalleled advantage in the investigation of ACAP1 signaling pathways. By selectively recognizing the phosphorylated form of ACAP1, this antibody enables researchers to gain valuable insights into the intricate mechanisms underlying cellular processes.

Crafted with utmost precision and rigorously validated, this antibody guarantees reliable and reproducible results, ensuring the utmost confidence in experimental outcomes. Its exceptional affinity for phosphorylated ACAP1 ensures minimal cross-reactivity, thereby enhancing the accuracy and specificity of experimental analyses.

The Phospho-ACAP1 (S554) Polyclonal Antibody is compatible with a wide range of applications, including Western blotting, immunoprecipitation, and immunofluorescence. Its versatility allows for seamless integration into diverse experimental protocols, empowering researchers to explore the multifaceted roles of ACAP1 in various biological contexts.

Furthermore, this antibody is manufactured using state-of-the-art techniques and undergoes rigorous quality control measures to ensure batch-to-batch consistency and optimal performance. Its long shelf life and stability make it an ideal choice for long-term research projects, providing researchers with a reliable and durable tool for their scientific endeavors.

In summary, the Phospho-ACAP1 (S554) Polyclonal Antibody represents a breakthrough in molecular biology research, offering unparalleled specificity, sensitivity, and versatility. With its exceptional performance and reliability, this antibody is poised to revolutionize the understanding of ACAP1 signaling pathways, paving the way for groundbreaking discoveries in the field.