Phospho-Bad (S134) Polyclonal Antibody

The protein encoded by BAD (BCL2 associated agonist of cell death) is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of BAD results in two transcript variants which encode the same isoform.

Introducing the Phospho-Bad (S134) Polyclonal Antibody, a cutting-edge scientific tool meticulously designed to facilitate advanced research in the field of molecular biology. This antibody, developed with utmost precision and expertise, is specifically tailored to detect and analyze the phosphorylation of Bad at serine 134, a crucial post-translational modification implicated in various cellular processes.

Crafted with the highest quality materials and employing state-of-the-art techniques, this polyclonal antibody exhibits exceptional sensitivity and specificity, ensuring accurate and reliable results. Its unique design enables it to recognize and bind to the phosphorylated form of Bad at serine 134 with unparalleled affinity, enabling researchers to delve deeper into the intricate mechanisms underlying cellular signaling pathways.

The Phospho-Bad (S134) Polyclonal Antibody is an indispensable tool for elucidating the role of Bad phosphorylation in diverse physiological and pathological contexts. Its application extends to a wide range of experimental techniques, including Western blotting, immunoprecipitation, immunofluorescence, and immunohistochemistry. With its versatility and robust performance, this antibody empowers researchers to explore the intricate interplay between phosphorylation events and cellular processes with utmost precision and accuracy.

Furthermore, this antibody has been rigorously validated through extensive testing, ensuring its reliability and reproducibility across various experimental conditions. Its exceptional performance is further enhanced by its compatibility with multiple species, including human, mouse, and rat, broadening its applicability and facilitating cross-species research.

In summary, the Phospho-Bad (S134) Polyclonal Antibody represents a breakthrough in molecular biology research, offering scientists an invaluable tool to unravel the complexities of cellular signaling pathways. With its exceptional sensitivity, specificity, and versatility, this antibody is poised to revolutionize the understanding of Bad phosphorylation and its implications in various physiological and pathological contexts.