Phospho-14-3-3 Theta/Tau (S232) Polyclonal Antibody

The protein encoded by PLN (phospholamban) is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in PLN are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy.

The Phospho-14-3-3 Theta/Tau (S232) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of phosphorylated 14-3-3 Theta/Tau protein at the serine 232 residue. This antibody is produced using advanced polyclonal antibody technology, ensuring exceptional quality and reliability.

The 14-3-3 family of proteins plays a crucial role in various cellular processes, including signal transduction, cell cycle regulation, and apoptosis. Phosphorylation of 14-3-3 Theta/Tau at the serine 232 site has been implicated in the modulation of protein-protein interactions and the regulation of cellular functions.

This polyclonal antibody has been extensively validated for its specificity and sensitivity in various experimental settings, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits minimal cross-reactivity with non-phosphorylated 14-3-3 Theta/Tau protein and other related proteins, ensuring accurate and reliable results.

The Phospho-14-3-3 Theta/Tau (S232) Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming antibody preparation. It is compatible with a wide range of sample types, including cell lysates, tissue extracts, and purified proteins.

With its exceptional performance and versatility, this antibody is an invaluable tool for researchers studying the role of phosphorylated 14-3-3 Theta/Tau protein in various biological processes. Its high specificity and sensitivity make it an ideal choice for both basic research and clinical applications.

Order the Phospho-14-3-3 Theta/Tau (S232) Polyclonal Antibody today and unlock new insights into the intricate mechanisms of cellular signaling and regulation.