Phospho-Cbl (Y700) Polyclonal Antibody

CBL (Cbl proto-oncogene) is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. CBL has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in CBL are also the cause of Noonan syndrome-like disorder.

The Phospho-Cbl (Y700) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of phosphorylated Cbl protein at tyrosine 700 residue. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the target protein.

Cbl protein plays a crucial role in various cellular processes, including signal transduction, cell proliferation, and immune response. Phosphorylation of Cbl at tyrosine 700 residue is known to regulate its function and downstream signaling pathways. Therefore, the Phospho-Cbl (Y700) Polyclonal Antibody serves as an invaluable tool for researchers studying the intricate mechanisms of Cbl protein and its involvement in cellular signaling.

The Phospho-Cbl (Y700) Polyclonal Antibody exhibits exceptional performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. It has been rigorously validated for its specificity and sensitivity, ensuring reliable and reproducible results. This antibody demonstrates minimal cross-reactivity with non-phosphorylated Cbl protein, further enhancing its specificity.

With its high-quality formulation, the Phospho-Cbl (Y700) Polyclonal Antibody offers superior performance and reliability, making it an ideal choice for researchers in the fields of cell biology, molecular biology, and immunology. Its versatility and accuracy make it an indispensable tool for investigating the role of phosphorylated Cbl protein in various physiological and pathological processes.

Order the Phospho-Cbl (Y700) Polyclonal Antibody today and unlock new insights into the intricate world of Cbl protein signaling.