Phospho-CaMKII Beta/Gamma/Delta (T287) Polyclonal Antibody

The product of CAMK2B (calcium/calmodulin dependent protein kinase II beta) belongs to the serine/threonine protein kinase family and to the Ca (2+) /calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of CAMK2B is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Alternative splicing results in multiple transcript variants.

The Phospho-CaMKII Beta/Gamma/Delta (T287) Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of phosphorylated Calcium/Calmodulin-dependent protein kinase II (CaMKII) isoforms, including Beta, Gamma, and Delta, at the threonine 287 residue. This antibody is produced using advanced polyclonal antibody technology, ensuring exceptional sensitivity and specificity.

CaMKII is a crucial regulator of various cellular processes, including synaptic plasticity, learning, and memory. Phosphorylation of CaMKII at the T287 residue is known to play a critical role in the activation and regulation of its enzymatic activity. Therefore, the Phospho-CaMKII Beta/Gamma/Delta (T287) Polyclonal Antibody serves as an invaluable tool for researchers aiming to investigate the functional significance of CaMKII phosphorylation in various biological systems.

This antibody exhibits outstanding performance in a wide range of applications, including Western blotting, immunoprecipitation, immunofluorescence, and immunohistochemistry. It has been rigorously validated to ensure high specificity and minimal cross-reactivity with non-phosphorylated forms of CaMKII and other related proteins. Additionally, it demonstrates excellent sensitivity, enabling the detection of low-abundance phosphorylated CaMKII isoforms.

The Phospho-CaMKII Beta/Gamma/Delta (T287) Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming antibody preparation. It is provided in a convenient format, allowing for easy storage and handling. Each batch of this antibody undergoes stringent quality control procedures to guarantee consistent performance and reproducibility.

In summary, the Phospho-CaMKII Beta/Gamma/Delta (T287) Polyclonal Antibody is an indispensable tool for researchers investigating the role of phosphorylated CaMKII isoforms in cellular signaling pathways. Its exceptional specificity, sensitivity, and versatility make it an ideal choice for a wide range of applications in both basic and clinical research.