Phospho-CD71 (S24) Polyclonal Antibody

CD71, also known as the transferrin receptor (TFR), is a type II membrane glycoprotein that exists as a disulfide-linked homodimer of two identical subunits. CD71 binds to two molecules of transferrin and a serum iron-transport protein, and directs the cellular uptake of iron via receptor-mediated endocytosis. CD71 is expressed, typically at high levels, on all proliferating cells, reticulocytes and erythroid precursors. It is not expressed on resting leukocytes, but is upregulated upon activation of lymphocytes, monocytes and macrophages. CD71 is also found on most dividing cells and on brain endothelium. A second transferrin receptor, TFR2, also mediates the uptake of transferrin-bound iron. TFR2 is a two-subunit homodimer and is highly expressed in liver as well as in hepatocytes and erythroid precursors. Mutations in the TFR2 gene result in hereditary hemochromatosis type III (HFE3), an iron overloading disorder predominant in Caucasians.

Introducing the Phospho-CD71 (S24) Polyclonal Antibody, a cutting-edge scientific tool meticulously designed to facilitate advanced research in the field of molecular biology. This antibody, derived from a polyclonal source, exhibits exceptional specificity and sensitivity, enabling precise detection and analysis of phosphorylated CD71 (S24) protein.

The Phospho-CD71 (S24) Polyclonal Antibody is meticulously manufactured using state-of-the-art techniques, ensuring consistent and reliable performance across various experimental conditions. Its high affinity for phosphorylated CD71 (S24) protein guarantees accurate and reproducible results, making it an indispensable asset for scientists engaged in elucidating the intricate mechanisms underlying cellular processes.

This antibody's exceptional specificity is attributed to its ability to selectively recognize the phosphorylated form of CD71 (S24) protein, thereby minimizing the risk of cross-reactivity with non-phosphorylated counterparts. This attribute empowers researchers to confidently investigate the role of CD71 (S24) phosphorylation in diverse biological contexts, including signal transduction pathways, cell cycle regulation, and cellular proliferation.

The Phospho-CD71 (S24) Polyclonal Antibody's remarkable sensitivity further enhances its utility in scientific investigations. Its superior detection capabilities enable the visualization and quantification of even low-abundance phosphorylated CD71 (S24) protein, facilitating the exploration of subtle molecular events that may have profound implications in disease progression and therapeutic interventions.

Moreover, this antibody's versatility extends to a wide range of applications, including Western blotting, immunoprecipitation, immunofluorescence, and immunohistochemistry. Its compatibility with multiple experimental techniques empowers researchers to employ diverse methodologies, thereby broadening the scope of their investigations and fostering comprehensive scientific discoveries.

In summary, the Phospho-CD71 (S24) Polyclonal Antibody represents a pinnacle of scientific innovation, offering researchers an invaluable tool to unravel the complexities of phosphorylated CD71 (S24) protein. With its exceptional specificity, sensitivity, and versatility, this antibody is poised to revolutionize molecular biology research, enabling groundbreaking advancements in our understanding of cellular processes and disease mechanisms.