Phospho-Caspase-9 (S144) Polyclonal Antibody

CASP9 (caspase 9) encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants.

The Phospho-Caspase-9 (S144) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of phosphorylated Caspase-9 at serine 144 residue. This antibody is produced using advanced techniques, ensuring high affinity and specificity towards the target protein.

Caspase-9 is a crucial enzyme involved in the initiation of apoptosis, a programmed cell death process. Phosphorylation of Caspase-9 at serine 144 has been identified as a key regulatory event in the activation of this enzyme. Therefore, the Phospho-Caspase-9 (S144) Polyclonal Antibody serves as an invaluable tool for researchers studying apoptosis and its associated signaling pathways.

This antibody exhibits exceptional performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been rigorously validated to ensure reliable and reproducible results across different experimental conditions. The high specificity of this antibody enables precise detection of phosphorylated Caspase-9, even in complex biological samples.

The Phospho-Caspase-9 (S144) Polyclonal Antibody is supplied as a liquid formulation, allowing for convenient and easy handling. It is provided in a ready-to-use format, eliminating the need for time-consuming preparation steps. The antibody is available in different sizes to accommodate various experimental requirements.

In summary, the Phospho-Caspase-9 (S144) Polyclonal Antibody is a superior research tool that enables accurate detection and quantification of phosphorylated Caspase-9. Its high specificity, sensitivity, and versatility make it an essential component for investigating apoptosis-related processes and signaling pathways.