Phospho-5-LO (S272) Polyclonal Antibody

ALOX5 encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The arachidonate 5-lipoxygenasen, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Introducing the Phospho-5-LO (S272) Polyclonal Antibody, a cutting-edge scientific tool meticulously designed to facilitate advanced research in the field of molecular biology. This antibody, derived from a polyclonal source, has been specifically engineered to target and detect phosphorylated 5-lipoxygenase (5-LO) at the serine 272 residue.

With its exceptional specificity and sensitivity, the Phospho-5-LO (S272) Polyclonal Antibody offers an unparalleled advantage in investigating the intricate signaling pathways involving 5-LO phosphorylation. By selectively binding to the phosphorylated serine 272 site, this antibody enables precise identification and quantification of phosphorylated 5-LO, thereby facilitating a comprehensive understanding of its functional implications.

Crafted with utmost precision and rigorously validated through extensive quality control measures, this antibody guarantees reproducible and reliable results, ensuring the utmost confidence in experimental outcomes. Its exceptional affinity for phosphorylated 5-LO, coupled with its low background noise, ensures optimal signal-to-noise ratios, thereby enhancing the accuracy and precision of data analysis.

The Phospho-5-LO (S272) Polyclonal Antibody is compatible with a wide range of applications, including Western blotting, immunoprecipitation, and immunofluorescence. Its versatility allows for seamless integration into diverse experimental protocols, empowering researchers to explore the multifaceted roles of phosphorylated 5-LO across various biological systems.

In summary, the Phospho-5-LO (S272) Polyclonal Antibody represents a breakthrough in molecular biology research, offering an indispensable tool for investigating the intricate mechanisms underlying 5-LO phosphorylation. With its exceptional specificity, sensitivity, and compatibility with various applications, this antibody is poised to revolutionize the understanding of 5-LO signaling pathways, paving the way for groundbreaking discoveries in the field.