Phospho-AMPKBeta1 (S182) Polyclonal Antibody

The protein encoded by PRKAB1 (protein kinase AMP-activated non-catalytic subunit beta 1) is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.

Introducing the Phospho-AMPKBeta1 (S182) Polyclonal Antibody, a cutting-edge scientific tool meticulously designed to facilitate advanced research in the field of molecular biology. This antibody, derived from a polyclonal source, exhibits exceptional specificity and sensitivity, enabling accurate detection and quantification of phosphorylated AMPKBeta1 at the serine 182 residue.

Crafted with utmost precision, this antibody undergoes rigorous quality control measures to ensure optimal performance and reproducibility. Its superior affinity towards the phosphorylated AMPKBeta1 epitope guarantees reliable and robust results, making it an indispensable asset for scientists engaged in elucidating the intricate mechanisms underlying cellular signaling pathways.

The Phospho-AMPKBeta1 (S182) Polyclonal Antibody boasts a wide range of applications, including but not limited to immunoblotting, immunoprecipitation, and immunofluorescence. Its versatility allows for seamless integration into diverse experimental setups, empowering researchers to explore the phosphorylation dynamics of AMPKBeta1 with unparalleled accuracy and precision.

Furthermore, this antibody exhibits exceptional stability and longevity, ensuring consistent performance over extended periods. Its compatibility with various sample types, including cell lysates and tissue extracts, further enhances its utility, enabling comprehensive investigations across multiple biological systems.

In summary, the Phospho-AMPKBeta1 (S182) Polyclonal Antibody represents a pinnacle of scientific innovation, offering researchers an invaluable tool to unravel the complexities of AMPKBeta1 phosphorylation. With its exceptional specificity, sensitivity, and versatility, this antibody is poised to revolutionize the field of molecular biology, empowering scientists to make groundbreaking discoveries and advance our understanding of cellular signaling pathways.