Phospho-ALK (Y1507) Polyclonal Antibody

ALK encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. ALK tyrosine kinase receptor comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).

Introducing the Phospho-ALK (Y1507) Polyclonal Antibody, a cutting-edge scientific tool meticulously designed to facilitate accurate detection and analysis of phosphorylated anaplastic lymphoma kinase (ALK) protein. This antibody, derived from a diverse pool of polyclonal sources, exhibits exceptional specificity and sensitivity, enabling researchers to delve into the intricate phosphorylation events occurring at tyrosine residue 1507 of the ALK protein.

Crafted with utmost precision, this antibody showcases an unparalleled affinity towards the phosphorylated form of ALK, ensuring reliable and reproducible results in a wide range of experimental applications. Its robust performance is attributed to the rigorous validation process it undergoes, guaranteeing optimal performance across various sample types, including cell lysates, tissue extracts, and immunoprecipitation assays.

The Phospho-ALK (Y1507) Polyclonal Antibody boasts an exceptional signal-to-noise ratio, enabling researchers to discern even the faintest phosphorylation events with utmost clarity. Its versatility extends to multiple research areas, including cancer biology, signal transduction, and kinase signaling pathways, empowering scientists to unravel the intricate mechanisms underlying ALK phosphorylation.

Furthermore, this antibody exhibits remarkable compatibility with various immunodetection techniques, including Western blotting, immunohistochemistry, and immunofluorescence, facilitating seamless integration into existing experimental workflows. Its robustness and reliability make it an indispensable tool for both basic research and clinical investigations, propelling scientific advancements in the field of ALK signaling.

In summary, the Phospho-ALK (Y1507) Polyclonal Antibody stands as a pinnacle of scientific innovation, offering researchers an invaluable resource to unravel the complexities of ALK phosphorylation. With its exceptional specificity, sensitivity, and compatibility, this antibody is poised to revolutionize the understanding of ALK signaling pathways and pave the way for groundbreaking discoveries in the realm of cancer biology and beyond.