Phospho-Cbl (Y674) Polyclonal Antibody

CBL (Cbl proto-oncogene) is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. CBL has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in CBL are also the cause of Noonan syndrome-like disorder.

The Phospho-Cbl (Y674) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of phosphorylated Cbl protein at tyrosine 674 residue. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the target protein.

Cbl protein plays a crucial role in various cellular processes, including signal transduction, cell proliferation, and immune response. Phosphorylation of Cbl at tyrosine 674 residue is known to regulate its function and downstream signaling pathways. Therefore, the Phospho-Cbl (Y674) Polyclonal Antibody serves as an invaluable tool for researchers studying the intricate mechanisms of Cbl protein and its involvement in cellular signaling.

The Phospho-Cbl (Y674) Polyclonal Antibody exhibits exceptional sensitivity and specificity, enabling accurate detection and quantification of phosphorylated Cbl protein in various sample types, including cell lysates and tissue extracts. This antibody has been extensively validated through rigorous testing, ensuring reliable and reproducible results.

Furthermore, the Phospho-Cbl (Y674) Polyclonal Antibody is compatible with a wide range of experimental techniques, including Western blotting, immunoprecipitation, and immunofluorescence. Its versatility allows researchers to explore different aspects of Cbl protein function and its role in various biological processes.

In summary, the Phospho-Cbl (Y674) Polyclonal Antibody is a highly reliable and specific tool for the detection and analysis of phosphorylated Cbl protein. Its exceptional sensitivity, compatibility with multiple experimental techniques, and extensive validation make it an indispensable asset for researchers investigating the intricate signaling pathways involving Cbl protein.