Phospho-CaSR (T888) Polyclonal Antibody

The protein encoded by CASR (calcium sensing receptor) is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in CASR cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism.

The Phospho-CaSR (T888) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of phosphorylated Calcium-Sensing Receptor (CaSR) at threonine 888 residue. This antibody is produced using advanced techniques and rigorous quality control measures to ensure optimal performance and reliability.

The Calcium-Sensing Receptor (CaSR) plays a crucial role in maintaining calcium homeostasis and regulating various physiological processes. Phosphorylation of CaSR at threonine 888 residue has been implicated in the modulation of receptor activity and downstream signaling pathways. Therefore, the Phospho-CaSR (T888) Polyclonal Antibody serves as an invaluable tool for researchers interested in investigating the functional significance of CaSR phosphorylation.

This antibody exhibits exceptional specificity towards the phosphorylated form of CaSR at threonine 888 residue, enabling precise and accurate detection in various experimental settings. It has been extensively validated through Western blotting, immunoprecipitation, and immunofluorescence techniques, ensuring reliable and reproducible results.

The Phospho-CaSR (T888) Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming and error-prone antibody preparation. It is compatible with a wide range of applications, including but not limited to immunohistochemistry, immunocytochemistry, and flow cytometry. The antibody exhibits excellent sensitivity, allowing for the detection of low-abundance phosphorylated CaSR in complex biological samples.

Furthermore, this antibody demonstrates minimal cross-reactivity with non-phosphorylated CaSR and other related proteins, ensuring specific and accurate detection. It exhibits high affinity and stability, enabling consistent and reliable performance across multiple experiments.

In summary, the Phospho-CaSR (T888) Polyclonal Antibody is a superior research tool that offers exceptional specificity, sensitivity, and reliability for the detection and analysis of phosphorylated Calcium-Sensing Receptor at threonine 888 residue. Its advanced design and rigorous quality control measures make it an indispensable asset for researchers investigating the functional role of CaSR phosphorylation in various biological processes.