Phospho-Brk (Y447) Polyclonal Antibody

The protein encoded by PTK6 (protein tyrosine kinase 6) is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of PTK6 in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of PTK6 has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple transcript variants.

Introducing the Phospho-Brk (Y447) Polyclonal Antibody, a cutting-edge scientific tool meticulously designed to facilitate advanced research in the field of molecular biology. This antibody, derived from a polyclonal source, exhibits exceptional specificity and sensitivity, enabling precise detection and quantification of phosphorylated Breast Tumor Kinase (Brk) at the tyrosine 447 residue.

Crafted with utmost precision and utilizing state-of-the-art technology, this antibody offers researchers an invaluable tool to investigate the intricate signaling pathways involving Brk phosphorylation. By targeting the specific phosphorylation site, Y447, this antibody enables the elucidation of Brk's role in various cellular processes, including cell proliferation, migration, and differentiation.

The Phospho-Brk (Y447) Polyclonal Antibody boasts an exceptional affinity for its target, ensuring reliable and reproducible results. Its high specificity guarantees minimal cross-reactivity with non-phosphorylated Brk or other related kinases, thereby enhancing the accuracy of experimental outcomes.

This antibody's versatility is further exemplified by its compatibility with various applications, including Western blotting, immunoprecipitation, and immunofluorescence. Its robust performance across multiple experimental techniques empowers researchers to explore Brk phosphorylation dynamics in diverse biological contexts.

Furthermore, the Phospho-Brk (Y447) Polyclonal Antibody is manufactured under stringent quality control measures, ensuring batch-to-batch consistency and reliability. Each vial is meticulously characterized to meet the highest standards of purity, potency, and specificity, guaranteeing optimal performance and reproducibility.

In summary, the Phospho-Brk (Y447) Polyclonal Antibody represents a breakthrough in molecular biology research, offering scientists an indispensable tool to unravel the intricate mechanisms underlying Brk phosphorylation. With its exceptional specificity, sensitivity, and compatibility with various applications, this antibody is poised to revolutionize the understanding of Brk-mediated signaling pathways.