Phospho-Bcl-2 (S70) Polyclonal Antibody

BCL2 encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants.

The Phospho-Bcl-2 (S70) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of phosphorylated Bcl-2 protein at serine 70 residue. Bcl-2 is a key regulator of apoptosis, playing a crucial role in maintaining cellular homeostasis and preventing excessive cell death. Phosphorylation at serine 70 has been shown to modulate the anti-apoptotic function of Bcl-2, making it an important target for research in various biological processes and diseases.

This polyclonal antibody has been meticulously developed using advanced immunization techniques, resulting in a high affinity and specificity towards phosphorylated Bcl-2 (S70). It has been rigorously validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. The antibody exhibits minimal cross-reactivity with non-phosphorylated Bcl-2 and other related proteins, ensuring accurate and reliable results.

With its exceptional sensitivity, this antibody enables the detection of even low levels of phosphorylated Bcl-2 (S70) in complex biological samples. Its robust performance and reproducibility make it an ideal choice for both qualitative and quantitative analysis of Bcl-2 phosphorylation status in diverse research areas, such as cancer biology, neurodegenerative diseases, and drug discovery.

The Phospho-Bcl-2 (S70) Polyclonal Antibody is supplied as a ready-to-use solution, ensuring convenience and ease of use. It is available in various sizes to accommodate different experimental needs. Each batch of antibody undergoes stringent quality control measures to guarantee consistent performance and lot-to-lot reproducibility.

In summary, the Phospho-Bcl-2 (S70) Polyclonal Antibody is a reliable and versatile tool for investigating the phosphorylation status of Bcl-2 at serine 70 residue. Its exceptional sensitivity, specificity, and robust performance make it an indispensable asset for researchers aiming to unravel the intricate mechanisms underlying apoptosis and related cellular processes.