Phospho-Bcl-6 (S333) Polyclonal Antibody

The protein encoded by BCL6 (B-cell CLL/lymphoma 6) is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. BCL6 is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for BCL6.

The Phospho-Bcl-6 (S333) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of phosphorylated Bcl-6 protein at serine 333 residue. Bcl-6 is a transcriptional repressor that plays a crucial role in the regulation of B-cell development and differentiation. Phosphorylation of Bcl-6 at serine 333 has been implicated in the modulation of its transcriptional activity and stability.

This polyclonal antibody has been meticulously developed using advanced immunization techniques and rigorously validated to ensure exceptional specificity and sensitivity. It exhibits minimal cross-reactivity with non-phosphorylated Bcl-6 protein, enabling precise and reliable detection of phosphorylated Bcl-6 at serine 333 residue.

The Phospho-Bcl-6 (S333) Polyclonal Antibody is suitable for various applications, including Western blotting, immunoprecipitation, immunofluorescence, and immunohistochemistry. It is compatible with a wide range of sample types, including cell lysates, tissue extracts, and formalin-fixed paraffin-embedded (FFPE) sections.

With its superior performance and versatility, this antibody is an indispensable tool for researchers studying the role of Bcl-6 phosphorylation in B-cell development, differentiation, and related diseases. Its high specificity and sensitivity ensure accurate and reproducible results, facilitating a deeper understanding of the molecular mechanisms underlying these processes.

Order the Phospho-Bcl-6 (S333) Polyclonal Antibody today and unlock new insights into the intricate regulatory pathways involving Bcl-6 phosphorylation.