Phospho-Caveolin-2 (Y27) Polyclonal Antibody

The protein encoded by CAV2 (caveolin 2) is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. CAV2 and related family member (CAV1) are located next to each other on chromosome 7, and express colocalizing proteins that form a stable hetero-oligomeric complex. Alternatively spliced transcript variants encoding different isoforms have been identified for CAV2. Additional isoforms resulting from the use of alternate in-frame translation initiation codons have also been described, and shown to have preferential localization in the cell (PMID: 11238462).

The Phospho-Caveolin-2 (Y27) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of phosphorylated Caveolin-2 protein. This antibody is produced using advanced techniques, ensuring its high affinity and specificity towards the phosphorylated form of Caveolin-2 at tyrosine residue 27.

Caveolin-2 is a key structural protein found in caveolae, specialized lipid rafts present in the plasma membrane. It plays a crucial role in various cellular processes, including signal transduction, endocytosis, and cholesterol homeostasis. Phosphorylation of Caveolin-2 at tyrosine residue 27 has been implicated in the regulation of its function and cellular localization.

The Phospho-Caveolin-2 (Y27) Polyclonal Antibody has been extensively validated for its performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits exceptional sensitivity and specificity, enabling accurate detection and quantification of phosphorylated Caveolin-2 in complex biological samples.

This antibody is supplied as a purified and lyophilized form, ensuring long-term stability and ease of storage. It is compatible with a wide range of experimental conditions and can be used in both research and clinical settings. Each batch of the antibody undergoes rigorous quality control procedures to ensure consistent and reliable results.

In summary, the Phospho-Caveolin-2 (Y27) Polyclonal Antibody is a valuable tool for researchers and scientists studying the role of Caveolin-2 phosphorylation in cellular processes. Its high specificity, sensitivity, and versatility make it an essential component of any study aiming to elucidate the molecular mechanisms underlying Caveolin-2 function.