Phospho-CD22 (Y807) Polyclonal Antibody

CD22, also known as Siglec-2 (sialic acid binding Ig-like lectin 2) or BL-CAM (B-lymphocyte cell adhesion molecule), is a 130-140 kDa, B-cell restricted, type I transmembrane glycoprotein belonging to the immunoglobulin gene superfamily. The expression of CD22 is developmentally regulated. It is expressed at low levels in the cytoplasm of pro-B and pre-B cells and present on the cell surface only at mature stages of B-cell differentiation. Cell surface expression is lost during terminal differentiation into plasma cell and after B-cell activation. CD22 is an inhibitory receptor for B-cell receptor (BCR) signalling, preferentially binds to alpha-2,6-linked sialic acid and mediates B-cell B-cell interactions. It plays a crucial role in activation and differentiation of the B-cell.

The Phospho-CD22 (Y807) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of phosphorylated CD22 protein. CD22 is a transmembrane glycoprotein that plays a crucial role in B-cell development and function. This polyclonal antibody has been raised against a synthetic peptide corresponding to the phosphorylated tyrosine 807 residue of CD22, ensuring its specificity towards the phosphorylated form of the protein.

The Phospho-CD22 (Y807) Polyclonal Antibody exhibits exceptional affinity and selectivity, enabling accurate detection and quantification of phosphorylated CD22 in various biological samples. It has been extensively validated for use in Western blotting, immunoprecipitation, immunofluorescence, and immunohistochemistry applications. This antibody demonstrates minimal cross-reactivity with non-phosphorylated CD22 and other related proteins, ensuring reliable and specific results.

With its high sensitivity, this antibody allows for the detection of low levels of phosphorylated CD22, making it an ideal tool for studying the regulation and signaling pathways involving CD22 phosphorylation. Its robust performance and reproducibility make it suitable for both basic research and clinical applications.

The Phospho-CD22 (Y807) Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size and concentration, ensuring cost-effectiveness and minimizing waste. Each batch of this antibody undergoes rigorous quality control testing to ensure consistent performance and reliability.

In summary, the Phospho-CD22 (Y807) Polyclonal Antibody is a highly specific and sensitive tool that enables the detection and analysis of phosphorylated CD22 protein. Its exceptional affinity, selectivity, and versatility make it an invaluable asset for researchers and clinicians studying CD22-related processes and diseases.