Phospho-AR (Y363) Polyclonal Antibody

The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. AR contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.

The Phospho-AR (Y363) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of phosphorylated Androgen Receptor (AR) at tyrosine 363 residue. This antibody is produced using advanced polyclonal antibody technology, ensuring exceptional quality and reliability.

The Phospho-AR (Y363) Polyclonal Antibody exhibits excellent specificity towards the phosphorylated form of AR at tyrosine 363, making it an ideal choice for researchers studying AR signaling pathways and related cellular processes. It has been extensively validated for use in various applications, including Western blotting, immunoprecipitation, and immunofluorescence.

This antibody demonstrates exceptional sensitivity, enabling the detection of low levels of phosphorylated AR in complex biological samples. Its high affinity and specificity ensure accurate and reliable results, facilitating precise quantification and analysis of AR phosphorylation events.

The Phospho-AR (Y363) Polyclonal Antibody is manufactured using state-of-the-art techniques and undergoes rigorous quality control measures to ensure batch-to-batch consistency and reproducibility. It is supplied as a ready-to-use solution, eliminating the need for time-consuming and error-prone antibody preparation.

With its superior performance characteristics and broad applicability, the Phospho-AR (Y363) Polyclonal Antibody is an indispensable tool for researchers investigating AR signaling pathways and its role in various physiological and pathological conditions. Its reliable and accurate results make it an invaluable asset in the field of molecular biology and biomedical research.