Phospho-Abl1 (T735) Polyclonal Antibody

ABL1 is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM: 151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons.

The Phospho-Abl1 (T735) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of phosphorylated Abl1 protein at threonine 735 residue. This antibody is produced using advanced polyclonal antibody production techniques, ensuring high affinity and specificity towards the target protein.

The Phospho-Abl1 (T735) Polyclonal Antibody exhibits exceptional performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. It enables researchers to investigate the phosphorylation status of Abl1 protein in different cellular contexts, facilitating a deeper understanding of its role in cellular signaling pathways.

This antibody has been rigorously validated using a variety of experimental approaches, ensuring reliable and reproducible results. It demonstrates minimal cross-reactivity with non-phosphorylated Abl1 protein, ensuring accurate detection and quantification of the phosphorylated form.

The Phospho-Abl1 (T735) Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming antibody preparation. It is provided in a convenient format, allowing for easy integration into existing laboratory protocols.

With its exceptional sensitivity, specificity, and versatility, the Phospho-Abl1 (T735) Polyclonal Antibody is an indispensable tool for researchers studying Abl1 protein phosphorylation and its implications in various biological processes.