Phospho-Caspase-8 (Y380) Polyclonal Antibody

CASP8 encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. Caspase 8 is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of Caspase 8 suggests that it may interact with Fas-interacting protein FADD. Caspase 8 was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.

The Phospho-Caspase-8 (Y380) Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of phosphorylated Caspase-8 (Y380) in various biological samples. This antibody is produced using high-quality polyclonal antibodies that have been purified and validated for use in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The Phospho-Caspase-8 (Y380) Polyclonal Antibody is an essential tool for researchers studying apoptosis and cell death pathways. It is highly specific to the phosphorylated form of Caspase-8 (Y380), which is a key regulator of apoptosis. This antibody has been extensively tested and validated for its specificity and sensitivity, ensuring reliable and reproducible results.

The Phospho-Caspase-8 (Y380) Polyclonal Antibody is supplied in a convenient and easy-to-use format, making it ideal for use in a wide range of applications. It is available in various sizes to suit different experimental needs and is compatible with a range of detection methods.

Overall, the Phospho-Caspase-8 (Y380) Polyclonal Antibody is a high-quality and reliable tool for researchers studying apoptosis and cell death pathways. Its specificity and sensitivity make it an essential tool for the detection of phosphorylated Caspase-8 (Y380) in various biological samples.