Phospho-20S Proteasome  Alpha3 (S250) Polyclonal Antibody

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMA3 (proteasome subunit alpha 3) encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified.

Introducing the Phospho-20S Proteasome Alpha3 (S250) Polyclonal Antibody, a cutting-edge scientific tool meticulously designed to facilitate advanced research in the field of proteasome biology. This high-quality antibody is specifically engineered to target the phosphorylated form of the 20S proteasome alpha3 subunit at serine 250, enabling precise detection and analysis of this crucial protein component.

Crafted with utmost precision and utilizing state-of-the-art technology, this polyclonal antibody exhibits exceptional specificity and sensitivity, ensuring accurate and reliable results in various experimental applications. Its affinity for the phosphorylated alpha3 subunit at serine 250 guarantees optimal performance, enabling researchers to delve deeper into the intricate mechanisms underlying proteasome-mediated protein degradation.

The Phospho-20S Proteasome Alpha3 (S250) Polyclonal Antibody boasts an extensive range of applications, including but not limited to immunoblotting, immunoprecipitation, immunofluorescence, and immunohistochemistry. Its versatility empowers researchers to explore diverse experimental setups, thereby facilitating comprehensive investigations into proteasome-related processes across various biological systems.

With its robust formulation and exceptional reproducibility, this antibody ensures consistent and reliable results, minimizing experimental variability and enhancing data accuracy. Its compatibility with multiple sample types, including cell lysates, tissue extracts, and purified proteins, further amplifies its utility, accommodating a wide range of experimental requirements.

Furthermore, this polyclonal antibody is manufactured under stringent quality control measures, adhering to the highest industry standards. Rigorous validation procedures guarantee its superior performance, providing researchers with the utmost confidence in their experimental outcomes.

In summary, the Phospho-20S Proteasome Alpha3 (S250) Polyclonal Antibody represents a pinnacle of scientific innovation, offering researchers an indispensable tool to unravel the intricate workings of proteasome biology. Its exceptional specificity, versatility, and reliability make it an invaluable asset in elucidating the complex mechanisms governing protein degradation. Elevate your research endeavors with this cutting-edge antibody and unlock new frontiers in proteasome research.