Phospho-Akt1 (S129) Polyclonal Antibody

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in AKT1 have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for AKT1.

Introducing the Phospho-Akt1 (S129) Polyclonal Antibody, a cutting-edge scientific tool meticulously designed to facilitate accurate and reliable detection of phosphorylated Akt1 at serine 129 residue. This high-quality antibody is specifically engineered to exhibit exceptional sensitivity and specificity, enabling researchers to delve into the intricate mechanisms underlying Akt1 signaling pathways.

Crafted with utmost precision, the Phospho-Akt1 (S129) Polyclonal Antibody boasts an advanced formulation that ensures optimal performance across a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. Its unrivaled affinity for phosphorylated Akt1 at serine 129 epitope guarantees unparalleled detection sensitivity, enabling researchers to obtain robust and reproducible results.

This antibody's polyclonal nature further enhances its versatility, enabling it to recognize multiple epitopes and exhibit minimal cross-reactivity with non-target proteins. This attribute, coupled with its exceptional specificity, ensures the utmost accuracy in detecting phosphorylated Akt1 at serine 129, thereby minimizing false-positive results and facilitating precise data interpretation.

The Phospho-Akt1 (S129) Polyclonal Antibody is meticulously manufactured using state-of-the-art techniques and undergoes rigorous quality control measures to ensure batch-to-batch consistency and reliability. Its exceptional performance is further fortified by its compatibility with various sample types, including human, mouse, and rat tissues, thereby broadening its applicability and facilitating seamless integration into diverse research settings.

Researchers can confidently rely on the Phospho-Akt1 (S129) Polyclonal Antibody to unravel the intricate intricacies of Akt1 signaling pathways, elucidating its role in various physiological and pathological processes. With its unparalleled sensitivity, specificity, and versatility, this antibody stands as an indispensable tool for scientists striving to advance their understanding of Akt1-mediated cellular signaling events.

In summary, the Phospho-Akt1 (S129) Polyclonal Antibody represents a pinnacle of scientific innovation, offering researchers an invaluable resource to explore the complexities of Akt1 signaling pathways with utmost precision and accuracy.