Phospho-ATF-1 (S63) Polyclonal Antibody

ATF1 encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of ATF1 and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. ATF1 has a pseudogene on chromosome 6.

Introducing the Phospho-ATF-1 (S63) Polyclonal Antibody, a cutting-edge scientific tool meticulously designed to facilitate advanced research in the field of molecular biology. This antibody, derived from a polyclonal source, exhibits exceptional specificity and sensitivity, enabling precise detection and analysis of phosphorylated ATF-1 at serine 63 residue.

Crafted with utmost precision and utilizing state-of-the-art technology, this antibody offers researchers an invaluable resource to unravel the intricate mechanisms underlying cellular signaling pathways. By targeting the phosphorylated form of ATF-1 at serine 63, this antibody empowers investigators to delve into the regulatory processes governing gene expression, cellular proliferation, and differentiation.

The Phospho-ATF-1 (S63) Polyclonal Antibody boasts an exceptional affinity for its target, ensuring reliable and reproducible results in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. Its robust performance guarantees accurate identification and quantification of phosphorylated ATF-1, facilitating comprehensive investigations into its functional roles and interactions within cellular networks.

Furthermore, this antibody exhibits remarkable versatility, accommodating various sample types, including cell lysates, tissue extracts, and whole-cell preparations. Its compatibility with multiple experimental platforms and techniques further enhances its utility, enabling seamless integration into diverse research workflows.

In addition to its exceptional performance, the Phospho-ATF-1 (S63) Polyclonal Antibody is manufactured under stringent quality control measures, ensuring batch-to-batch consistency and reliability. Rigorous validation procedures, including specificity testing and cross-reactivity assessments, guarantee the antibody's specificity for phosphorylated ATF-1 at serine 63, minimizing the risk of false-positive or false-negative results.

Researchers seeking to unravel the intricate regulatory mechanisms governing cellular processes can rely on the Phospho-ATF-1 (S63) Polyclonal Antibody as an indispensable tool. Its unparalleled specificity, sensitivity, and versatility make it an invaluable asset in elucidating the complex interplay between phosphorylated ATF-1 and cellular signaling pathways.