Phospho-Abl1 (Y204) Polyclonal Antibody

ABL1 is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM: 151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons.

The Phospho-Abl1 (Y204) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of phosphorylated Abl1 protein at tyrosine 204 residue. This antibody is produced using advanced polyclonal antibody production techniques, ensuring high affinity and specificity towards the target protein.

The Abl1 protein plays a crucial role in various cellular processes, including cell growth, differentiation, and apoptosis. Phosphorylation of Abl1 at tyrosine 204 residue is known to regulate its activity and downstream signaling pathways. Therefore, the Phospho-Abl1 (Y204) Polyclonal Antibody serves as an invaluable tool for researchers studying the functional implications of Abl1 phosphorylation.

This antibody has been rigorously validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits exceptional sensitivity and specificity, enabling accurate and reliable detection of phosphorylated Abl1 protein in complex biological samples.

The Phospho-Abl1 (Y204) Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming antibody preparation. It is compatible with a wide range of sample types, including cell lysates, tissue extracts, and purified proteins.

With its exceptional performance and versatility, the Phospho-Abl1 (Y204) Polyclonal Antibody is an indispensable tool for researchers investigating the role of Abl1 phosphorylation in various biological processes. Its high specificity and sensitivity make it an ideal choice for both basic research and drug development studies.