Phospho-CD3 Zeta (Y142) Polyclonal Antibody

The protein encoded by CD247 (CD247 molecule) is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for CD247.

The Phospho-CD3 Zeta (Y142) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of phosphorylated CD3 Zeta protein at tyrosine 142 residue. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the target protein.

The CD3 Zeta protein plays a crucial role in T cell receptor (TCR) signaling, which is essential for the activation and regulation of T cells. Phosphorylation of CD3 Zeta at tyrosine 142 residue is known to be involved in the initiation of downstream signaling cascades, leading to T cell activation and immune response.

The Phospho-CD3 Zeta (Y142) Polyclonal Antibody has been rigorously validated for its performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits excellent sensitivity and specificity, enabling accurate detection and quantification of phosphorylated CD3 Zeta protein in complex biological samples.

This antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size, ensuring cost-effective and efficient experiments. The Phospho-CD3 Zeta (Y142) Polyclonal Antibody is compatible with a wide range of species, including human, mouse, and rat, making it suitable for diverse research applications.

In summary, the Phospho-CD3 Zeta (Y142) Polyclonal Antibody is a reliable and powerful tool for the investigation of CD3 Zeta phosphorylation events. Its high specificity, sensitivity, and versatility make it an indispensable asset for researchers studying T cell signaling pathways and immune responses.