Phospho-Catenin-Beta (T41/S45) Polyclonal Antibody

Catenin beta 1 encoded by CTNNB1 is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. Catenin beta 1 also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, catenin beta 1 binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in CTNNB1 are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for CTNNB1.

The Phospho-Catenin-Beta (T41/S45) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of phosphorylated Catenin-Beta at threonine 41 and serine 45 residues. This antibody is produced using advanced techniques, ensuring high affinity and specificity towards the target protein.

Catenin-Beta is a crucial component of the Wnt signaling pathway, playing a pivotal role in cell adhesion and gene transcription regulation. Phosphorylation of Catenin-Beta at threonine 41 and serine 45 residues has been implicated in various cellular processes, including cell proliferation, differentiation, and migration.

The Phospho-Catenin-Beta (T41/S45) Polyclonal Antibody exhibits exceptional performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. It has been extensively validated for its specificity and sensitivity, ensuring reliable and reproducible results.

This antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size, allowing for multiple experiments without compromising its quality. The Phospho-Catenin-Beta (T41/S45) Polyclonal Antibody is compatible with a wide range of sample types, including cell lysates, tissue extracts, and purified proteins.

With its exceptional specificity and sensitivity, the Phospho-Catenin-Beta (T41/S45) Polyclonal Antibody is an indispensable tool for researchers studying the Wnt signaling pathway and its implications in various cellular processes. Its reliable performance and ease of use make it an ideal choice for both basic research and drug development studies.

Order the Phospho-Catenin-Beta (T41/S45) Polyclonal Antibody today and unlock new insights into the intricate mechanisms of cellular signaling pathways.