Phospho-Catenin-Beta (S37) Polyclonal Antibody

Catenin beta 1 encoded by CTNNB1 is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. Catenin beta 1 also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, catenin beta 1 binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in CTNNB1 are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for CTNNB1.

Introducing the Phospho-Catenin-Beta (S37) Polyclonal Antibody, a cutting-edge scientific tool meticulously designed to facilitate advanced research in the field of molecular biology. This antibody, derived from a polyclonal source, exhibits exceptional specificity and sensitivity, enabling accurate detection and analysis of the phosphorylated form of Catenin-Beta at serine 37 residue.

Crafted with utmost precision, this antibody showcases unparalleled affinity towards the phosphorylated Catenin-Beta, ensuring reliable and reproducible results. Its robust performance is attributed to the rigorous quality control measures implemented during its production, guaranteeing optimal functionality and consistency across experiments.

The Phospho-Catenin-Beta (S37) Polyclonal Antibody is an invaluable asset for elucidating the intricate signaling pathways involving Catenin-Beta phosphorylation. By selectively targeting the phosphorylated form of Catenin-Beta, this antibody empowers researchers to unravel the underlying mechanisms governing cellular processes, such as cell adhesion, migration, and proliferation.

With its versatility, this antibody serves as an indispensable tool for a wide range of applications, including immunoblotting, immunoprecipitation, immunofluorescence, and immunohistochemistry. Its compatibility with various experimental techniques ensures seamless integration into diverse research methodologies, facilitating comprehensive investigations into the role of Catenin-Beta phosphorylation in cellular physiology and pathology.

Furthermore, the Phospho-Catenin-Beta (S37) Polyclonal Antibody is engineered to deliver exceptional performance across multiple species, including human, mouse, and rat. This cross-reactivity broadens the scope of its application, enabling researchers to explore evolutionary conserved aspects of Catenin-Beta phosphorylation across different organisms.

In summary, the Phospho-Catenin-Beta (S37) Polyclonal Antibody represents a pinnacle of scientific innovation, meticulously designed to empower researchers in unraveling the intricate molecular mechanisms involving Catenin-Beta phosphorylation. With its exceptional specificity, sensitivity, and versatility, this antibody serves as an indispensable tool for advancing our understanding of cellular processes and their implications in various biological contexts.