Phospho-BRCA1 (S1423) Polyclonal Antibody

BRCA1 (BRCA1, DNA repair associated) encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in BRCA1 are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for BRCA1, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.

Introducing the Phospho-BRCA1 (S1423) Polyclonal Antibody, a cutting-edge scientific tool meticulously designed to facilitate advanced research in the field of molecular biology. This antibody, derived from a polyclonal source, exhibits exceptional specificity and sensitivity, enabling precise detection and analysis of the phosphorylated form of BRCA1 at serine 1423.

Crafted with utmost precision and utilizing state-of-the-art technology, this antibody offers researchers an invaluable resource for investigating the intricate mechanisms underlying BRCA1 phosphorylation. Its polyclonal nature ensures a diverse range of epitope recognition, enhancing the versatility and reliability of experimental outcomes.

The Phospho-BRCA1 (S1423) Polyclonal Antibody boasts an exceptional affinity for the phosphorylated form of BRCA1 at serine 1423, enabling researchers to discern even the subtlest changes in phosphorylation levels. This antibody's high specificity guarantees minimal cross-reactivity, ensuring accurate and reliable results.

Furthermore, this antibody's superior sensitivity empowers researchers to detect low-abundance phosphorylated BRCA1 molecules, thereby facilitating the exploration of rare cellular events and signaling pathways. Its robust performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence, further amplifies its utility in diverse experimental settings.

In addition to its exceptional performance, this antibody is manufactured under stringent quality control measures, ensuring batch-to-batch consistency and reproducibility. Rigorous testing and validation procedures guarantee the antibody's reliability, enabling researchers to confidently pursue their scientific inquiries.

The Phospho-BRCA1 (S1423) Polyclonal Antibody represents a pivotal advancement in the realm of molecular biology research, offering scientists an indispensable tool to unravel the complexities of BRCA1 phosphorylation. With its unparalleled specificity, sensitivity, and versatility, this antibody is poised to revolutionize the understanding of BRCA1-related cellular processes and contribute to the development of novel therapeutic strategies.

Choose the Phospho-BRCA1 (S1423) Polyclonal Antibody today and embark on a transformative journey of scientific discovery.