Phospho-Bcr (Y177) Polyclonal Antibody

A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. BCR, RhoGEF and GTPase activating protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for BCR.

The Phospho-Bcr (Y177) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of phosphorylated Bcr protein at tyrosine 177 residue. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the target protein.

The Phospho-Bcr (Y177) Polyclonal Antibody is meticulously validated for its performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits exceptional sensitivity, enabling the detection of even low levels of phosphorylated Bcr protein in complex biological samples.

This antibody is manufactured under stringent quality control measures to ensure batch-to-batch consistency and reproducibility. It is produced using high-quality materials and state-of-the-art techniques, resulting in a reliable and robust product that consistently delivers accurate and reproducible results.

The Phospho-Bcr (Y177) Polyclonal Antibody is an indispensable tool for researchers studying the role of Bcr protein phosphorylation in various cellular processes, including signal transduction, cell proliferation, and differentiation. Its high specificity and sensitivity make it an ideal choice for investigating the functional significance of Bcr phosphorylation in disease states, such as cancer and leukemia.

In summary, the Phospho-Bcr (Y177) Polyclonal Antibody is a superior research tool that offers exceptional sensitivity, specificity, and reproducibility. Its application in various experimental techniques makes it an invaluable asset for researchers aiming to unravel the intricate mechanisms underlying Bcr protein phosphorylation.