Phospho-Bcl-x (T47) Polyclonal Antibody

The protein encoded by BCL2L1 (BCL2 like 1) belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator.

The Phospho-Bcl-x (T47) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of phosphorylated Bcl-x protein in various biological samples. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the phosphorylated form of Bcl-x.

The Phospho-Bcl-x (T47) Polyclonal Antibody has been extensively validated for its performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits exceptional sensitivity and selectivity, enabling accurate and reliable detection of phosphorylated Bcl-x protein even at low expression levels.

This antibody is derived from a rabbit host, ensuring excellent immunoreactivity and minimal cross-reactivity with non-target proteins. It has been rigorously tested against a wide range of species, including human, mouse, and rat, making it suitable for diverse research purposes.

The Phospho-Bcl-x (T47) Polyclonal Antibody is supplied as a liquid formulation, allowing for easy and convenient handling. It is provided in a ready-to-use format, eliminating the need for time-consuming preparation steps. The antibody is also available in different sizes to accommodate various experimental requirements.

With its exceptional performance and reliability, the Phospho-Bcl-x (T47) Polyclonal Antibody is an indispensable tool for researchers studying the role of phosphorylated Bcl-x protein in cellular processes, such as apoptosis and cancer development. Its high specificity and sensitivity make it an ideal choice for both basic research and clinical applications.