Phospho-ASK 1 (S83) Polyclonal Antibody

Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK.

Introducing the Phospho-ASK 1 (S83) Polyclonal Antibody, a cutting-edge scientific tool meticulously designed to facilitate advanced research in the field of molecular biology. This antibody, derived from a polyclonal source, exhibits exceptional specificity and sensitivity, enabling precise detection and quantification of ASK 1 phosphorylation at serine residue 83.

Crafted with utmost precision and utilizing state-of-the-art technology, the Phospho-ASK 1 (S83) Polyclonal Antibody offers researchers an invaluable resource for investigating the intricate signaling pathways involving ASK 1. Its high affinity for the phosphorylated form of ASK 1 ensures accurate and reliable results, empowering scientists to delve deeper into the mechanisms underlying cellular processes.

This antibody's exceptional performance is a testament to its rigorous development process, which involved stringent quality control measures to guarantee optimal functionality and reproducibility. Its robustness and reliability make it an indispensable tool for a wide range of applications, including immunoblotting, immunoprecipitation, and immunofluorescence assays.

The Phospho-ASK 1 (S83) Polyclonal Antibody is supplied in a convenient and user-friendly format, ensuring ease of use and compatibility with various experimental setups. Its versatility extends to multiple species, making it suitable for diverse research models.

In summary, the Phospho-ASK 1 (S83) Polyclonal Antibody represents a breakthrough in molecular biology research, offering scientists an unparalleled tool to unravel the complexities of ASK 1 signaling pathways. With its exceptional specificity, sensitivity, and reliability, this antibody is poised to revolutionize the field and drive scientific advancements in understanding cellular processes at a molecular level.