Phospho-AR (S650) Polyclonal Antibody

The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. AR contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.

Introducing the Phospho-AR (S650) Polyclonal Antibody, a cutting-edge scientific tool meticulously designed to facilitate advanced research in the field of molecular biology. This antibody, derived from a polyclonal source, exhibits exceptional specificity and sensitivity, enabling precise detection and analysis of phosphorylated Androgen Receptor (AR) at the serine 650 residue.

Crafted with utmost precision and utilizing state-of-the-art technology, the Phospho-AR (S650) Polyclonal Antibody offers researchers an invaluable resource for investigating the intricate mechanisms underlying AR phosphorylation. Its high affinity for the phosphorylated AR at serine 650 ensures accurate and reliable results, empowering scientists to unravel the complex signaling pathways associated with AR activation.

This antibody's exceptional performance is attributed to its meticulous development process, which involves rigorous quality control measures to guarantee optimal specificity and minimal cross-reactivity. Its polyclonal nature further enhances its versatility, enabling it to recognize multiple epitopes and thus facilitating a comprehensive understanding of AR phosphorylation dynamics.

The Phospho-AR (S650) Polyclonal Antibody's versatility extends beyond traditional Western blotting applications. It is also compatible with immunoprecipitation, immunofluorescence, and immunohistochemistry techniques, broadening the scope of experimental possibilities. Its robust performance across various experimental platforms ensures seamless integration into diverse research workflows, enabling scientists to explore AR phosphorylation with unparalleled accuracy and efficiency.

Furthermore, this antibody is manufactured in strict adherence to the highest industry standards, ensuring consistent and reliable results across experiments. Its long shelf life and stability guarantee prolonged usability, making it an indispensable tool for long-term research projects.

In summary, the Phospho-AR (S650) Polyclonal Antibody represents a breakthrough in molecular biology research, offering scientists an exceptional tool to investigate the intricate world of AR phosphorylation. With its unparalleled specificity, sensitivity, and versatility, this antibody empowers researchers to unravel the complexities of AR signaling pathways, paving the way for groundbreaking discoveries in the field.