Phospho-AR (S213) Polyclonal Antibody

The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. AR contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.

Introducing the Phospho-AR (S213) Polyclonal Antibody, a cutting-edge scientific tool meticulously designed to facilitate advanced research in the field of molecular biology. This antibody, derived from a polyclonal source, exhibits exceptional specificity and sensitivity, enabling precise detection and analysis of phosphorylated Androgen Receptor (AR) at the serine 213 residue.

Crafted with utmost precision and utilizing state-of-the-art technology, this Phospho-AR (S213) Polyclonal Antibody offers researchers an invaluable resource for investigating the intricate mechanisms underlying AR phosphorylation. Its high affinity for the phosphorylated AR at serine 213 ensures accurate and reliable results, empowering scientists to unravel the complex signaling pathways associated with AR activation.

The Phospho-AR (S213) Polyclonal Antibody boasts an exceptional level of selectivity, exhibiting minimal cross-reactivity with non-phosphorylated AR or other related proteins. This attribute guarantees the utmost specificity, minimizing the risk of false-positive or false-negative outcomes, thereby enhancing the credibility of experimental findings.

Furthermore, this antibody demonstrates remarkable sensitivity, enabling the detection of even low levels of phosphorylated AR at serine 213. This heightened sensitivity broadens the scope of research possibilities, facilitating the exploration of subtle changes in AR phosphorylation dynamics and their potential implications in various physiological and pathological contexts.

The Phospho-AR (S213) Polyclonal Antibody is meticulously validated through rigorous quality control measures, ensuring consistent and reproducible results across experiments. Its robust performance, coupled with its ease of use, makes it an indispensable tool for researchers seeking to delve deeper into the intricate world of AR phosphorylation.

In summary, the Phospho-AR (S213) Polyclonal Antibody represents a breakthrough in molecular biology research, offering unparalleled specificity, sensitivity, and reliability. With its exceptional performance and meticulous design, this antibody empowers scientists to unravel the complexities of AR phosphorylation, paving the way for groundbreaking discoveries in the field.