Phospho-Akt1 (T450) Polyclonal Antibody

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in AKT1 have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for AKT1.

The Phospho-Akt1 (T450) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of phosphorylated Akt1 at threonine 450 residue. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the target protein.

Phosphorylation of Akt1 at threonine 450 plays a crucial role in the regulation of various cellular processes, including cell survival, proliferation, and metabolism. The Phospho-Akt1 (T450) Polyclonal Antibody enables researchers to investigate the activation status of Akt1 and its downstream signaling pathways in a wide range of biological samples.

This antibody has been rigorously validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits exceptional sensitivity and specificity, allowing for accurate and reliable detection of phosphorylated Akt1 at threonine 450 residue.

The Phospho-Akt1 (T450) Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming antibody preparation. It is compatible with various experimental conditions and can be used in both routine laboratory settings and high-throughput screening applications.

With its exceptional performance and reliability, the Phospho-Akt1 (T450) Polyclonal Antibody is an indispensable tool for researchers studying Akt1 signaling pathways and its involvement in various physiological and pathological processes.