Phospho-Akt (S473) Polyclonal Antibody

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in AKT1 have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for AKT1.

Introducing the Phospho-Akt (S473) Polyclonal Antibody, a cutting-edge scientific tool meticulously designed to facilitate accurate and reliable detection of phosphorylated Akt at serine 473 residue. This antibody, crafted with utmost precision and expertise, offers an unparalleled level of specificity and sensitivity, enabling researchers to delve into the intricate mechanisms underlying Akt signaling pathways.

The Phospho-Akt (S473) Polyclonal Antibody showcases exceptional performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. Its remarkable affinity for phosphorylated Akt at serine 473 ensures optimal signal detection, thereby facilitating the elucidation of Akt-mediated cellular processes with utmost precision and clarity.

With its robust and reliable performance, this antibody serves as an invaluable asset in diverse research areas, such as cancer biology, cell signaling, and drug discovery. Its ability to discern phosphorylated Akt at serine 473 with utmost accuracy empowers scientists to unravel the intricate interplay between Akt and downstream effectors, shedding light on critical cellular events and paving the way for novel therapeutic interventions.

The Phospho-Akt (S473) Polyclonal Antibody is meticulously manufactured using state-of-the-art techniques, ensuring batch-to-batch consistency and reproducibility. Rigorous quality control measures are implemented throughout the production process to guarantee optimal performance and reliability, thereby instilling confidence in researchers seeking to unravel the complexities of Akt signaling.

In summary, the Phospho-Akt (S473) Polyclonal Antibody represents a pinnacle of scientific innovation, offering researchers an indispensable tool to explore the intricate world of Akt signaling. Its exceptional specificity, sensitivity, and reliability make it an indispensable asset in elucidating the mechanisms underlying Akt-mediated cellular processes, ultimately driving advancements in various fields of biomedical research.