Phospho-Abl1/2 (Y393/439) Polyclonal Antibody

ABL1 is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM: 151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons.

The Phospho-Abl1/2 (Y393/439) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of phosphorylated Abl1 and Abl2 proteins. This antibody is produced using advanced techniques, ensuring its high affinity and specificity towards the phosphorylated tyrosine residues at positions 393 and 439 of Abl1 and Abl2, respectively.

With its exceptional performance, this polyclonal antibody enables researchers to investigate the activation status of Abl1 and Abl2 kinases in various biological samples. It is particularly useful in studying signal transduction pathways involving Abl1 and Abl2, as well as their roles in cellular processes such as proliferation, differentiation, and apoptosis.

The Phospho-Abl1/2 (Y393/439) Polyclonal Antibody exhibits minimal cross-reactivity with non-phosphorylated forms of Abl1 and Abl2, ensuring accurate and reliable results. It is compatible with various experimental techniques, including Western blotting, immunoprecipitation, and immunofluorescence, allowing for versatile applications in both basic research and clinical studies.

This antibody is supplied in a ready-to-use format, providing convenience and time-saving benefits to researchers. It is produced under stringent quality control measures, ensuring batch-to-batch consistency and reproducibility. Additionally, it is validated for use in multiple species, including human, mouse, and rat, broadening its applicability across different research models.

In summary, the Phospho-Abl1/2 (Y393/439) Polyclonal Antibody is a reliable and efficient tool for investigating the phosphorylation status of Abl1 and Abl2 proteins. Its high specificity, sensitivity, and compatibility with various experimental techniques make it an invaluable asset for researchers in the field of signal transduction and cellular biology.