Phospho-4E-BP1 (T46) Polyclonal Antibody

EIF4EBP1 encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.

The Phospho-4E-BP1 (T46) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of phosphorylated 4E-BP1 at threonine residue 46. This antibody is produced using advanced polyclonal antibody technology, ensuring exceptional quality and reliability.

Phosphorylation of 4E-BP1 at threonine 46 is a critical event in the regulation of protein translation initiation. By specifically targeting this phosphorylation site, the Phospho-4E-BP1 (T46) Polyclonal Antibody enables researchers to investigate the dynamic changes in 4E-BP1 phosphorylation levels, providing valuable insights into cellular signaling pathways and protein synthesis regulation.

This antibody exhibits excellent sensitivity and specificity, allowing for accurate and reproducible results in various experimental applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been extensively validated in multiple cell lines and tissues, ensuring its suitability for a wide range of research areas.

The Phospho-4E-BP1 (T46) Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming antibody preparation. It is provided in a convenient format, allowing for easy storage and handling.

With its exceptional performance and reliability, the Phospho-4E-BP1 (T46) Polyclonal Antibody is an indispensable tool for researchers studying protein translation regulation, cellular signaling, and related fields.