Phospho-4E-BP1 (T37) Polyclonal Antibody

EIF4EBP1 encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.

The Phospho-4E-BP1 (T37) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of phosphorylated 4E-BP1 at threonine 37 residue. This antibody is produced using advanced polyclonal antibody technology, ensuring exceptional quality and reliability.

Phosphorylation of 4E-BP1 at threonine 37 plays a crucial role in regulating protein translation initiation and is involved in various cellular processes, including cell growth, proliferation, and survival. The Phospho-4E-BP1 (T37) Polyclonal Antibody has been extensively validated for its specificity and sensitivity in various experimental settings, including Western blotting, immunohistochemistry, and immunofluorescence.

This antibody exhibits a high affinity for phosphorylated 4E-BP1 at threonine 37, enabling accurate and precise detection of this critical post-translational modification. Its exceptional sensitivity allows for the detection of low abundance phosphorylated 4E-BP1, making it an ideal tool for studying signaling pathways and protein regulation.

The Phospho-4E-BP1 (T37) Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming and error-prone antibody preparation. Its robust formulation ensures consistent and reproducible results, making it suitable for both routine laboratory use and high-throughput applications.

With its exceptional specificity, sensitivity, and reliability, the Phospho-4E-BP1 (T37) Polyclonal Antibody is an indispensable tool for researchers studying protein translation initiation, cellular signaling, and related fields.